Studying the effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life, researchers from the University of Tehran conducted a double-blind, randomised, placebo-controlled trial with 142 women aged between 20 and 35 years of age.
The study participants were randomly allocated to either the zinc sulfate or placebo group. Women in the intervention group received zinc sulfate 220mg capsules (containing 50mg elemental zinc ) from the 16th day of their menstrual cycle to the second day of the next cycle.
Using the Premenstrual Symptoms Screening Tool (PSST) and 12-item Short-Form Health Survey Questionnaire to extract data from the groups, the researchers found the prevalence of moderate to severe PMS in the ZS group significantly decreased throughout the study period (9.5% in the first, 6% in the second and 2.6% in the third month of the study, P < 0.001), but in the control placebo group this reduction was seen only in the first month of the study (14.2% in the first, 13.7% in the second and 13.5% in the third month, P = 0.08).
“The zinc sulfate group improved the PSST component scores throughout the study period and the mean scores of quality of life in physical and mental components were significantly improved in the zinc sulfate intervention group. However, the differences were statistically significant only three months after the intervention,” the researchers stated.
With millions of Australian women suffering from one or more symptoms of premenstrual syndrome every month, the results of this study offer hope for a simple effective treatment.
“Zinc sulfate, as a simple and inexpensive treatment, was associated with improvement of PMS symptoms and health-related quality of life, however, additional studies are warranted to confirm these findings,” the authors concluded.
J Obstet Gynaecol Res. 2017 Feb 11. doi: 10.1111/jog.13299. [Epub ahead of print]